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Shivhare, U. D.
- Formulation of Clotrimazole Vaginal Suppository Containing Lacto bacillus Spores
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Authors
Affiliations
1 MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
1 MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
Source
Asian Journal of Pharmacy and Technology, Vol 3, No 1 (2013), Pagination: 5-8Abstract
Human vagina represents a dynamic ecosystem dominated by certain species of Lactobacillus. This microorganism restricts the growth of pathogens by using properties of steric exclusion and inhibitory substance production. Serious complications including bacterial vaginosis and vaginal cancer are often determined in women with reduced numbers of lactobacilli. Local application of Lactobacillus is consequently promising to keep the vagina colonized by this strain, which consequently reduces the infections. The first objective of this research was to develop a local application pharmaceutical formulation of a vaginal suppository containing lyophilized culture of Lactobacillus with anti microbial agent clotrimazole. The second objective was to establish a stable clotrimazole suppositiry alone with Lactic acid Bacillus Spores for vaginosis.Keywords
Vaginosis,Lactic acid bacillus Spores, Clotrimazole, Formulation, Viability, Stability
References
- Penn RL. Gynecological and obstetrical infections. In: Reese RE, Gordon Douglas Jr. R, 2nd ed. A practical approach to infectious diseases. Boston: Little, Brown and Company; 1986.p.385-421.
- Thadepalli H, Gorbach SL, Keith L. Anaerobic infections of the female genital tract; bacteriologic and therapeutic aspects. Am-J Obstet Gynecol 1973;117:1034-40.
- Ledger WJ. Micro-organisms that cause infection. In: Ledger WJ, ed. Infections in the female. 2nd ed. Philadelphia: Lea & Febiger;1986.p.9-34.
- Ledger WJ. Antimicrobial agents. In: Ledger WJ,2nd ed. Infections in the female. Philadelphia: Lea & Febiger;1986.p.95- 126.
- Bleker OP, Folkertsma K, Dirks-Go SIS. Diagnostic procedures in vaginitis. Eur J Obstet Gynecol Reprod Biol 1989;31:10-11.
- Bleker OP, Folkertsma K, Dirks-Go SIS. Diagnostic procedures in vaginitis. Eur J Obstet Gynecol Reprod Biol 1989;31:179-83.
- McFarland LV. Beneficial microbes: health or hazard? Eur J Gastroenterol Hepatol 2000;12:1069-1071.
- Gionchetti P, Rizzello F, Venturi A, Campieri M. Probiotics in infective diarrhoea and inflammatory bowel diseases. J Gastroenterol Hepatol 2000;15:489-493.
- Larsen B. Vaginal flora in health and disease. Clin Obstet Gynecol 1993; 36:107-121.
- Redondo-Lopez V, Cook RL, Sobel JD. Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora. Rev Infect Dis 1990; 12:856-872.
- Hiller SL. The vaginal microbial ecosystem and resistance to HIV. AIDS Res Hum Retroviruses 1998; 14(suppl 1):17-21.
- Boris S, Barbes C. Role played by lactobacilli in controlling the population of vaginal pathogens. Microbes Infect 2000;2:543- 546.
- Sobel JD. Vaginitis. N Engl J Med 1997; 337:1896-1903. 14. McGregor JA, French JI. Bacterial vaginosis in pregnancy. Obstet Gynecol Surv 2000;55(suppl 5):1-19.
- Sweet RL. Role of bacterial vaginosis in pelvic inflammatory diseases. J Infect Dis 1995; 20(suppl 2):271-275.
- Sooper DE. Bacterial vaginosis and postoperative infections. Am J Obstet Gynecol 1993; 169:467-469.
- Van de Wijgert, J.H.H.M, Mason P.R, Gwanzura L. Intravaginal practices, vaginal £ora disturbances, and acquisition of sexually transmitted diseases in Zimbabwean women. J. Infect. Dis. 2000;181,587-594.
- Chaim W, Mazor M, Leiberman J.R.The relationship between bacterial vaginosis and preterm birth. Arch. Gynecol. Obstet.1997;259: 51-58.
- 19.Reid G. and Bruce, A.W. Selection of Lactobacillus strains for urogenital probiotic applications. J. Infect. Dis. 2001;183 (Suppl.1),77-80.
- Reid G, Bruce, A.W. and Taylor, M. Instillation of Lactobacillus and stimulation of indigenous organisms to prevent recurrence of urinary tract infections. Microecol Ther 1995;23:32-45.
- Ritter. W. Pharmacokinetic fundamentals of vaginal treatment with clotrimazole. Am J Obstet Gynecol 1985;152:5-7.
- Gachotte D, Pierson CA, Lees ND, Barbuch R, Koegel C, Bard M. A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme. Proc Natl Acad Sci U S A. 1997; 94(21):11173-8
- Pastorek JG, CotchMF, Martin DH, Eschenbach DA. Vaginal Infections and Prematurity Study Group: clinical and microbiological correlates of vaginal trichomoniasis during pregnancy. Clin Infect Dis 1996;23:1075-80.
- Warrilow AG, Martel CM, Parker JE, Melo N, Lamb DC, Nes WD, Kelly DE, Kelly SL. Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrob Agents Chemother. Epub 2010 Oct;54(10):4235-45.
- Sorvillo F, Kerndt P. Trichomonas vaginalis and amplifications of HIV- 1 transmission. Lancet 1998; 351(9097):213-4.
- Sanae K, and Nattha K, Formulation and Evaluation of Vaginal Suppositories Containing Lactobacillus, World Academy of Science, Engineering and Technology 2009;(31):630-633
- Formulation development and release studies of indomethacin suppositories, ML sah, TR Saini, short communications, Ind. J. pharm. Sciences 2008;70(4):498-501.
- Naikwade Sonali R, Kulkarni Pratibha P, Jathar Shripad R, Bajaj Amrita N. DARU 2008;16(3):119-127.